Extremely low Sensitivity of Coronary Risk Equations

Old arteries frequently undetected by AGLA, PROCAM, and SCORE, upcoming study, view results here
Coronary Risk Equations have a low sensitivity to detect subjects at high coronary risk (reference) 

Lies, damned lies about the cost-efficiency of statins ….(reference)

You can now participate in a GP Study named CPLAQUE. More…

Atherosclerosis Progression, LDL and Statins

A substantial proportion of patients with coronary artery disease fail to achieve effective reductions in LDL-C, despite prescription of statin therapy. Greater progression of atherosclerosis is observed in these patients. Our current study underscores monitoring LDL-C level after the commencement of statin to ensure adequate response to statin therapy. More
The presence and extent of nonobstructive CAD predicted mortality. Baseline statin therapy was associated with a significant reduction in mortality for individuals with nonobstructive CAD but not for individuals without CAD. More

Statins in Primary Prevention – the discussion is finally over

The Cholesterol Treatment Trialist performed a metaanalysis on 134’537 patients and were able to calculate risk reduction with statins for all risk strata in primary care. Their findings are remarkable. More…

IMT is not suited for tracking cardiovascular risk.

A metaanalysis published on Lancet 2012 has included 36’985 participants and found that IMT changes can not predict future cardiovascular risk. More…

Lipid lowering reduces intracranial stenosis

This is the first prospective multicenter study to demonstrate that high-density lipoprotein cholesterol elevation, along with remnant lipoprotein cholesterol reduction and low apolipoprotein B/A-I, is associated with prevention of angiographic progression of symptomatic intracranial atherosclerotic stenosis. More…

Longterm TPA Follow Up Study (15 years)

A longterm TPA follow-up study from the Tromso cohort revealed that in subjects without plaque annual risk is 7/1000, which is about the risk to experience a myocardial infarction using nuclear scans (refer to TPALongtermTromso2014.pdf). IMT further reduced risk to 4/1000 per year, if IMT was found to be below 0.71 mm. Therefore, in subjects without plaque, IMT offers a small further risk stratificitaion from low risk to very low risk.

Statins and Prostate Cancer

Recent scientific information points to the possibility, that statins reduce the severity of the clinical course in patients affected by prostate cancer. Link